Minimal stimulation in vitro fertilization (IVF) with a freeze-all approach gives acceptable live birth rates in an overall poor prognosis population

Abstract

Minimal stimulation IVF typically utilizes daily clomiphene citrate and 3 low doses of gonadotropin injections on stimulation days 5, 7, and 9. Minimal stimulation cycles are planned with the intention to freeze all available embryos exclusively at blastocyst stage. After reasonable embryo accumulation, frozen embryo transfer (FET) is performed. There is a paucity of published data on the outcomes of minimal stimulation IVF with a freeze-all protocol in patients with diminished ovarian reserve (DOR) and/or a prior history of traditional IVF failures.