Abstract
Vibrio cholerae neuraminidase (VCN) has been shown to have an adjuvant effect predominantly for the cellular immune response when admixed with a variety of antigens. On the basis of these findings, the therapeutic effect of specific immunotherapy with the use of VCN was evaluated on the growth of metastases of Lewis lung adenocarcinoma in C57B1/6 mice. Tumor immunotherapy was performed after complete excision of the primary tumor graft and after an adapted chemotherapy (cyclophosphamide) by intradermal injection of increasing numbers of tumor cells (105 – 107) mixed with increasing amounts of VCN (0–65 mU). This procedure has already been described as “chessboard vaccination”.
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