Abstract
Clarithromycin is recognised as the key antibiotic for Helicobacter pylori treatment, since it has the most powerful bactericidal effect in vitro compared to other available molecules. Unfortunately, primary clarithromycin resistance is increasing worldwide, and it is regarded as the main factor reducing the efficacy of eradication therapy. Clarithromycin resistance assessment is currently performed by agar dilution method or Epsilometer (E-test). Both these tools require bacterial culture, are time-consuming and show a low sensitivity, even in expert hands.
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