Abstract
To examine the haemolytic effects of amino acid and dextrose solutions on co-infused packed red blood cells. An in vitro study of packed cells co-infused at various rates with dextrose 5%, 10%, 15% and intravenous amino acid solution (Vamin; Kabi-Pharmacia, Baxter Healthcare Pty Ltd) in dextrose 5%, 10% and 15%. The degree of haemolysis was measured as free oxyhaemoglobin by spectrophotometer. Co-infused 0.9% saline and water were used as 0% and 100% haemolysis controls. Only minimal haemolysis was observed with the solutions tested. The greatest observed amount of haemolysis was 0.14%. Co-infusion of packed red blood cells with dextrose and amino acid solutions at the concentrations and infusion rates commonly used in neonatal care, does not cause clinically important haemolysis.
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