Abstract

Questions Schistosomiasis is one of the most common parasitic infections of humans worldwide. The eggs of Schistosoma mansoni induce chronic liver inflammation and are involved in hepatic carcinogenesis, especially hepatocellular carcinoma HCC. The minichromosome maintenance protein (MCM) complex is a helicase controling cell-cycle DNA replication. MCM expression is highly increased in HCC patients. Therefore, we analysed whether the MCM complex is also upregulated during S. mansoni infection.

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