Abstract
AbstractUltraviolet (UV)‐induced nonmelanoma skin cancer requires a number of genetic changes before tumors can develop. To determine the sequence of these changes; we performed a series of functional studies by investigating the spontaneously immortalized human skin keratinocyte HaCaT cell line. We established a multistep in vitro carcinogenesis model that allowed us to place known (mutational inactivation of the tumor suppressor gene p53, ras oncogene activation) and novel (loss of chromosome 3p as carrier of “senescence” gene(s) and chromosome 15 as carrier of a tumor suppressor gene as well as telomerase up‐regulation) genetic alterations involved in the process of skin carcinogenesis in chronological order. © 1995 Wiley‐Liss, Inc.
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