Mini-Review and Our Experience of Methimazole-Related Omphalomesenteric Duct Remnant, Omphalocele, and Esophageal Atresia

Abstract

Methimazole MMI carbimazole CMZ a prodrug of MMI and propylthiouracil PTU are used to treat hyperthyroidism during pregnancy However the use of MMI CMZ in pregnancy particularly during organogenesis is subject to precautions or warnings because of the risk of neonatal congenital malformations The risk of congenital malformations is recognized but the epidemiology of MMI CMZ related congenital malformations is not well known in Japan Our mini review introduced the recent papers and our retrospective study which evaluated the medical records of patients with surgery for omphalomesenteric duct remnant omphalocele and esophageal atresia between and and the treatment history of the mothers to determine use of MMI during pregnancy Our study revealed the mothers of six of the patients had Graves rsquo disease and all had been treated with MMI during pregnancy No mother of any patient undergoing surgery for these conditions had been treated with MMI during pregnancy after the package insert had been revised to inform MMI prescription is contraindicated in early gestational weeks leading to restricted prescription in Japan Our data is consistent with the current notion of MMI CMZ embrynopathy the teratogenicity of these drugs words