Abstract
To compare metabolite ratios in the posterior cingulate with the Mini-Mental State Examination (MMSE) test scores in patients with mild or moderate Alzheimer disease and in controls.MethodsWe evaluated 29 patients with mild or moderate Alzheimer disease and 15 controls by proton spectroscopy with the voxel located in the posterior cingulate. The MMSE was applied to all patients and controls. The metabolic ratios: N-acetyl-aspartate/creatine (Naa/Cr), mio-inositol/creatine (mI/Cr) and mio-inositol/N-acetyl-aspartate (mI/Naa) were obtained and then post-processed using the MRUI software (magnetic resonance user interface).ResultsCorrelation between Naa/Cr and mI/Naa ratios in the posterior cingulate with the MMSE was observed, and a positive correlation with Naa/Cr and negative correlation with mI/Naa were seen. The mI/r ratio presented no correlation with MMSE scores.ConclusionThe positive correlation with Naa/Cr, and negative correlation with mI/Naa may corroborate that neuronal density/viability is associated to a higher MMSE score.
Highlights
To compare metabolite ratios in the posterior cingulate with the Mini-Mental State Examination (MMSE) test scores in patients with mild or moderate Alzheimer disease and in controls
In Alzheimer disease (AD) N-acetil aspartate concentration or N-acetyl-aspartate/creatine (Naa/Cr) ratio are decreased while mio-inositol concentration, mio-inositol/ creatine and mio-inositol/N-acetyl-aspartate/creatine ratios are increased.[2]
A significant association was observed between Naa/ Cr and ml/Naa ratios in the posterior cingulate and the MMSE
Summary
To compare metabolite ratios in the posterior cingulate with the Mini-Mental State Examination (MMSE) test scores in patients with mild or moderate Alzheimer disease and in controls. Methods: We evaluated 29 patients with mild or moderate Alzheimer disease and 15 controls by proton spectroscopy with the voxel located in the posterior cingulate. Métodos: Nós avaliamos 29 pacientes com doença de Alzheimer leve e moderada e 15 controles utilizando espectroscopia de prótons com volume de interesse único localizado no cíngulo posterior. As razões dos metabólitos N-acetil-aspartato/creatina (Naa/Cr), mio-inositol/creatina (mI/Cr) e mio-inositol/-acetil-aspartato (mI/Naa) foram obtidas e pós-processadas usando o software MRUI (magnetic resonance user interface). Palavras-chave: espectroscopia de prótons, cíngulo posterior, volume de interesse único, escore do teste MEEM, doença de Alzheimer.
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