Abstract
Aldosterone is the major mineralocorticoid in the human body and is produced in the zona glomerulosa of the cortex in the adrenal glands, and its secretion is stimulated by angiotensin II, adrenocorticotrophic hormone, catecholamines, and local potassium levels. Its levels in plasma are elevated 4-fold in heart failure (HF).1 Through a variety of mechanisms, aldosterone is believed to play a role in the pathogenesis and progression of left ventricular dysfunction.2 The mineralocorticoid receptor antagonists (MRAs) spironolactone and eplerenone have consistently demonstrated a 20% reduction in mortality and 21% reduction in sudden death, which has been counterbalanced by a 6% to 12% risk of hyperkalemia (potassium >6.0 mEq/L) depending on the baseline estimated glomerular filtration rate.3,4,5 Article see p 586 In this issue of Circulation: Heart Failure , O’Meara and colleagues report on a retrospective analysis from …
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
