Abstract
Two experiments were conducted, using a total of 220 young male albino rats, to study the effects of thyroxine on the response to varying intakes of Mg. Weight gain, tissue mineral composition, mineral balance, serum and kidney glycoprotein were criteria of response. Thyroxine reduced the weight gain but did not influence the Mg required for optimal weight gain at a given thyroxine level, nor did it affect the Mg required for normal levels of Mg in blood serum or in bone ash; however, thyroxine did prevent the kidney calcification normally occurring in Mg-deficient animals but did not prevent calcification of heart muscle. Blood serum glycoprotein was reduced by thyroxine although kidney glycoprotein was not affected. Balances of Ca, P and Mg were reduced by thyroxine, mainly as a result of reduced apparent absorption of these minerals.
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