MINERAL METABOLISM AND BONE MINERAL DENSITY IN PATIENTS WITH CENTRAL HYPOGONADISM AS INDICATORS OF PREMATURE AGING

Abstract

Aim of this study was to estimate the markers of mineral turnover and BMD in young women with the central hypogonadism, to compare them with healthy young women and healthy postmenopausal women of middle/advanced age. Materials and methods. One hundred seventy women were included in the study: 73 patients with the central hypogonadism (isolated hypogonadism n=35, hypopituitarism n=38), age of 25 [21.2; 30.5] y.o., amenorrhea duration 5 [2.3; 10.1] years; 47 healthy women with regular menstrual cycles, age 24 [23.1; 28.0] y.o., and 50 healthy women with natural menopause, age 56 [53; 58] y.o., menopause duration 6.0 [2.1; 10.0] years. Groups did not differ by age. Results. In patients with central female hypogonadism concentrations of calcium and alkaline phosphatase were significantly higher than in healthy women of similar age, however did not differ from the parameters in postmenopausal women. T-scores <-2.5 SD in lumbar spine were noted in 55% and 28% patients with central hypogonadism and in menopause respectively (р<0.001), and in a hip - 27% and 7%, respectively (r=0.002). The factors promoting lower values of BMD in young women with central hypogonadism were the amenorrhea duration, low level of total testosterone, primary amenorrhea. Distinctions of mineral turnover and BMD in isolated hypogonadism and a hypopituitarism were not revealed. Conclusions. Central hypogonadism in women at young age is a higher prognostic factor of low BMD than natural menopause, and might be considered as a marker of premature aging.