Mineral-Associated Medicinal Plants: Uncovering Their Anti-inflammatory Potential Through Comprehensive Exploration of Bioactive Compounds And Pharmacological Activities

Abstract

In recent years, there has been a growing interest in harnessing the potential of bioactive compounds sourced from specific wild plants with inherent natural anti-inflammatory properties. Inflammation is a complex physiological response crucial for defense against adverse stimuli. However, prolonged inflammation can give rise to a myriad of health issues, particularly when influenced by factors related to mineral exposure and processing. This review aims to provide an overview of the current status of knowledge regarding the anti-inflammatory plant-based drugs which have been derived from green tea, licorice, devil's claw, willow bark, chamomile, Salvia officinalis and Piper ovatum etc. Bioactive compounds such as catechins, glycyrrhizin, harpagoside, salicin, chamazulene, Lactones and alkaloids which are referred as secondary plant metabolites obtaining the pharmacological effects in human beings and animals. It has long been identified by the authors of various classical texts of Ayurveda and their properties, indications to inhibit the production of pro-inflammatory cytokines and enzymes which helps to modulate various signaling pathways involved in inflammation. This study delves into the assessment of the anti- inflammatory properties of select wild plants while taking into consideration their potential interactions with mineral and mineral-associated pollutants. Safety and potential side effects are discussed in the context of metal exposure scenarios. Additionally, it underscores the necessity for continued research to elucidate the action mechanisms of these plant-derived compounds, further unlocking their therapeutic potential and efficacy in addressing inflammation heightened by mineral- related factors.