Mind-Body Therapies for Cancer Patients Living with Depression, Anxiety or Insomnia (MIRACLE): A Systematic Review with Individual Participant Data Network Meta-Analysis.

Yoann Birling,Mingxian Jia,Jing Liu,Zahra Ayati,Zhichao Yu,Deep Jyoti Bhuyan,Sarah Nevitt,Paul Fahey,Linda Ellen Carlson,Liyi Nyiam,Tiffany Pham,Fan Feng

doi:10.3390/mps4040076

Abstract

Depression, anxiety, and insomnia are common in cancer patients. Mind-body therapies (MBTs) are promising forms of treatment for cancer patients living with depression, anxiety, and insomnia. The objective of this study is to assess the effectiveness and acceptability of MBTs in cancer patients living with depression, anxiety, or insomnia. EMBase, PubMed, Cinahl, PsychINFO, IndMED, CSI-NISCAIR, CNKI, Clinicaltrial.gov, ChiCTR, and CTRI will be searched until October 2020 for relevant studies. Randomized controlled studies in which MBTs were tested in a cancer population will be selected. The authors of the selected studies will be contacted to obtain individual participant data. The participants who reached a defined clinical threshold for depression, anxiety, or insomnia will be selected for the three sub-studies on depression, anxiety, and insomnia, respectively. Pairwise and network meta-analyses will be used to assess the changes in depression, anxiety, sleep quality, and completion rate. We will assess the effect of the treatment dose (number and frequency of interventions) on effectiveness. The results of this study will inform clinical decision-making for the treatment of psychological disturbances in cancer patients. If MBTs are found effective, they will potentially be recommended as treatments for cancer patients with psychological symptoms.

Highlights

Licensee MDPI, Basel, Switzerland.Psychological disturbances are highly prevalent in cancer patients
Context, treatments targeting different aspects of physical and psychological health have a decisive advantage in the treatment of psychological disturbances in cancer patients
Depression, anxiety, and insomnia significantly impair the quality of life of cancer patients

Summary

Introduction

Licensee MDPI, Basel, Switzerland.Psychological disturbances are highly prevalent in cancer patients. It is estimated that approximately 25%, 10%, and 28% of cancer patients suffer from clinical depression, anxiety, and insomnia, respectively [1,2], which is roughly double the rates of the general population [3,4,5,6] This higher prevalence can be attributed to the shock caused by a cancer diagnosis [7], the burden of cancer treatment [8], and the correlations between different psychological symptoms and between these symptoms and fatigue and pain [9,10,11,12,13,14]. The effective management of psychological symptoms improves both adherence to anti-cancer treatment and mortality rates [22,23,24]

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