Abstract
Enantioselective identification of chiral molecules holds immense significance in the fields of biological processes, chemical reactions, and drug development due to the optical rotation properties of enantiomers. Moreover, the chiral nanocomposite plays an important role in capable of selectively interacting with specific chiral molecules. By utilizing the chiral surfaces of metal polyphenol framework, an enantioselective identification chiral nanocomposite is fabricated on polyphenol colloidal spheres (PCS). The multivariate metal-based nanocomposite use L-tartaric acid (TA) and copper as a chiral recognition selector and signal corrector, aminothiophenol (PATP) anchoring Ag NPs as artificial traction skeleton. Applying L-/ D-cysteine as patterns enantiomers, the chiral recognition selector Cu- L-TA framework perform stereoselective recognition of target molecules through strong affinity and hydrogen interaction. The discriminative SERS signal and CT-related totally symmetric (a1) value of Cu- PCS@Ag NPs and PATP molecules is regarded as discriminating part and internal standard to correct the signal drifting. The put forward method has a good linearity in the concentration range of 1 nM ∼ 10 mM and detection limits as low as 0.37 pM and 0.30 pM for L/D-Cys. This work provides specific method for the chiral molecule recognition and determination in complex matrix sample.
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