Abstract
Postmenopausal osteoporosis is a global health problem characterized by decreased in bone mineral density (BMD) and progressive deterioration of microarchitecture and subsequent increase in bone fragility and susceptibility to fracture. More than 200 million people suffer from osteoporosis worldwide with about 8.9 million fractures and the prevalence rate of osteoporosis is expected to increase significantly in the future because of increased in life expectancy and aging population. Milk-derived bioactive peptides from cow, goat, sheep, buffalo, and camel exhibit several potential health promoting effect including antiosteoporosis, antihypertensive, antioxidative, antithrombotic, immunomodulatory and anti-inflammatory effects. Epidemiological and intervention studies have shown that milk and milk-derived peptides prevented bone loss in pre- and postmenopausal women. Moreover, quite a lot of studies have reported that milk-derived bioactive peptides can induce osteoblast cell proliferation, differentiation and also prevented bone loss in osteoporotic rats model. Thus, milk-derived peptides exhibits beneficial effect against bone-related diseases and can be of particular interest towards prevention and management of postmenopausal osteoporosis. Hence, the present review summarizes various studies using ISI, SCOPUS and PubMed indexed journals to elucidate the potential role of milk-derived bioactive peptides with in vitro and in vivo antiosteoporotic property
Highlights
Postmenopausal osteoporosis is a global health problem forming-osteoblast cell differentiation and maturation (Wu and characterized by decreased in bone mineral density (BMD) and Lu, 2008)
The Several risk factors for postmenopausal osteoporosis includes biological activity of these bioactive peptides depends on their aging, hormonal, and genetic factors, which are unmodifiable amino acid composition and sequences (Sánchez and Vázquez, while life style, smoking, excessive alcohol intake, 2017)
A key regulator of bone metabolism is the antiosteoporotic effect milk-derived bioactive peptides and responsible for maintaining delicate balance between bone elucidate their possible mechanism of actions in the forming-osteoblast cells and bone degrading-osteoclast cells prevention and management of postmenopausal osteoporosis (Manolagas, 2010)
Summary
Postmenopausal osteoporosis is a global health problem forming-osteoblast cell differentiation and maturation (Wu and characterized by decreased in bone mineral density (BMD) and Lu, 2008). The prevalence of osteoporosis functions (Sharma et al, 2011; Walther and Sieber, 2011; is expected to rise significantly in the future because of Shahidi and Zhong, 2008) These bioactive peptides are usually increase in life expectancy and aging population Antibacterial peptides possess strong antibacterial activity against the expression vector and comparative sensitivity to proteolytic enzymes activity (Espita et al, 2009) Though, some of these limitations may possibly be overcome by expression of these bioactive peptides in the form of fusion protein or in a tandem gene that may counteract their inherent toxic properties and improve their expression levels
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
