Mild sustained physiological hyperglycemia impairs hepatic insulin sensitivity in healthy individuals with normal glucose tolerance

Abstract

Previous studies have shown that chronic hyperglycemia exacerbates skeletal muscle insulin resistance and worsens β-cell function. However, the effect of sustained physiologic hyperglycemia on hepatic insulin sensitivity stays unclear. This paper is the Chinese translation of Mild physiologic hyperglycemia induces hepatic insulin resistance in healthy normal glucose-tolerant participants , published on Journal of Clinical Endocrinology & Metabolism [Tripathy D, Merovci A, Basu R, et al. J Clin Endocrinol Metab, 2019, 104(7): 2842-2850] after obtaining the copyright of the original journal. This study examined the effect of sustained physiologic hyperglycemia on endogenous glucose production(EGP) in 16 healthy individuals with three-step hyperinsulinemic euglycemic clamp. The results showed that sustained physiologic hyperglycemia for only 48 hours increased the rate of basal hepatic glucose production and induced hepatic insulin resistance in healthy persons with normal glucose tolerance, indicating the role of glucotoxicity in the increase of hepatic glucose production in type 2 diabetes. Key words: Hyperglycemia; Insulin resistance; Normal glucose tolerance