Abstract
BackgroundThe aim of the study was to investigate the effect of mild cerebral hypoxia on haemoglobin oxygenation (HbO2), cerebrospinal fluid dynamics and cardiovascular physiology. To achieve this goal, four signals were recorded simultaneously: blood pressure, heart rate / electrocardiogram, HbO2 from right hemisphere and changes of subarachnoid space (SAS) width from left hemisphere. Signals were registered from 30 healthy, young participants (2 females and 28 males, body mass index = 24.5 ± 2.3 kg/m2, age 30.8 ± 13.4 years).ResultsWe analysed the recorded signals using wavelet transform and phase coherence. We demonstrated for the first time that in healthy subjects exposed to mild poikilokapnic hypoxia there were increases in very low frequency HbO2 oscillations (< 0.052 Hz) in prefrontal cortex. Additionally, SAS fluctuation diminished in the whole frequency range which could be explained by brain oedema.ConclusionsConsequently the study provides insight into mechanisms governing brain response to a mild hypoxic challenge. Our study supports the notion that HbO2 and SAS width monitoring might be beneficial for patients with acute lung disease.
Highlights
Hypoxia is frequently observed in a number of clinical situations such as lung disease, sleep apnoea, as well as cardiac and cerebrovascular dysfunction associated with aging
The atmospheric pressure for whole time of experiment was kept at the same level 712 mmHg, while the level of oxygen during normobaric hypoxia was reduced to 14.8%
The novel findings of our study showed that mild poikilocapnic hypoxia increases the very low frequency Haemoglobin oxygenation (HbO2) oscillations (< 0.052 Hz) in prefrontal cortex while diminishing subarachnoid space (SAS) oscillations in the whole frequency range
Summary
Hypoxia is frequently observed in a number of clinical situations such as lung disease, sleep apnoea, as well as cardiac and cerebrovascular dysfunction associated with aging. A number of cognitive and neuropsychiatric manifestations of SARS have been observed in a proportion of patients such as depressed mood, anxiety, It is well-known that hypoxia leads to a decline in haemoglobin oxygenation (HbO2) in cerebral cortex [2]. The aim of the study was to investigate the effect of mild cerebral hypoxia on haemoglobin oxy‐ genation (HbO2), cerebrospinal fluid dynamics and cardiovascular physiology. To achieve this goal, four signals were recorded simultaneously: blood pressure, heart rate / electrocardiogram, HbO2 from right hemisphere and changes of subarachnoid space (SAS) width from left hemisphere.
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