Abstract
Background/Aim: To investigate which FSH, recombinant or urinary, works better in low responders patients after initial stimulation with clomiphene citrate (CC) and antagonist protocol. Matherial and Methods: Retrospective study with historical controls in an University-affiliated infertility center. A total of 140 patients with a previous low response in an IVF / ICSI cycle were included. 70 patients undergoing GnRH antagonist cycle received controlled ovarian stimulation with oral clomiphene citrate (CC) and human menopausal gonadotropins (Group A). Similarly, 70 patients were stimulated with oral CC and a recombinant follicle-stimulating hormone (rFSH) and recombinant Luteinizing hormone (LH) combination(Group B). The primary outcome was clinical pregnancy and implantation rate; secondary outcome variables were duration of stimulation and canceled cycles. Result(S): There were no differences between the groups (A vs B) respect to the clinical pregnancy rate (29.1% vs. 31.6%) or implantation rate (27.4% vs. 29.8%). The duration of the stimulation was similar (10.1 vs. 10.8 days), but this difference was not significant. Conclusions: More studies are required to optimize the CC/gonadotropin stimulation protocol. A possible benefit of rFSH/rLH in this soft protocol was not shown.
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