Mild Michael Addition of Glycine Imines to Aromatic Nitroalkenes Catalyzed by DBU with LiOTf as an Additive

Abstract

A mild michael addition of glycine imines to aromatic-nitroalkenes catalyzed by 10 mol% dbu with liotf as an additive was developed. in most cases, the products could be obtained in good yields (up to 96%) with moderate to good diastereoselectivities (up to 10:1). the selectivity for syn adduct can be reversed to anti when the r group of glycine imines was changed from methyl or ethyl to tert-butyl.