Abstract
Parkinson’s disease (PD) is associated with an increased incidence of cognitive impairment and dementia. Population-based cohort of 25 patients with incident PD underwent a large neuropsychological battery. Executive functions were the most affected cognitive domain including particularly initiation, mental flexibility and inhibition. Episodic memory and visuo-spatial functions were less affected. We found that 92% of patients were classified as having Mild Cognitive Impairment (MCI); most of them experienced PD-MCI Single-Domain (17 patients) with disturbances on executive functions. Less frequently, we identified a group of patients with multiple-domain PD-MCI demonstrating deficits on executive functions as well as on episodic memory and/or visuospatial capacities.
Highlights
Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease [1], characterized by its motor features including rigidity, bradykinesia and postural instability
We found that 92% of patients were classified as having Mild Cognitive Impairment (MCI); most of them experienced PD-MCI Single-Domain (17 patients) with disturbances on executive functions
We identified a group of patients with multiple-domain PD-MCI demonstrating deficits on executive functions as well as on episodic memory and/or visuospatial capacities
Summary
Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease [1], characterized by its motor features including rigidity, bradykinesia and postural instability. Cognitive disorders are frequent in early PD even in the absence of cognitive complains [3]. They are noted in 30% of patients at the moment of diagnosis [4]. They refer to brain processes underlying: response initiation, inhibition, control ability in set-switching, complex problem solving, retrieval abilities, organizational strategies, concept formation, working memory, attention decision-making and perseveration [5]
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