Abstract
Results The therapeutic response evaluated in Hamilton Scale for Depression(HAM-D), Montgomery and Asberg Depression Rating Scale (M.A.D.R.S. ), Mini Mental State Examination (M.M.S.E.) and Global Clinical Impression (G.C.I.) scores during 8 months. In the third group who received the two drugs associated, had much better response than the others and “brain enhancer”. Conclusions The group who received the combination of the nootropic agent Galantamine with antidepressant (SSRIs) Escitalopram had a relevant satisfactory therapeutic response (the best result), so there is a possible relation between the deficit in cholinergic systems and depression. Could be cerebral cholinergic systems deficit a generator of Depressive Disorder? Attention and memory functions are closely tied to the cholinergic neurotransmitter system. The cholinergic system is one of the neurotransmitter systems implicated in the pathophysiology of mood disorders. Evidence suggests that during major depressive episodes, the cholinergic system is hypersensitive to acetylcholine.
Highlights
To evaluate the efficacy of galantamine-escitalopram combination in patients with Mild Cognitive Disorder and Depression
The group who received the combination of the nootropic agent Galantamine with antidepressant (SSRIs) Escitalopram had a relevant satisfactory therapeutic response, so there is a possible relation between the deficit in cholinergic systems and depression
Could be cerebral cholinergic systems deficit a generator of Depressive Disorder?
Summary
To evaluate the efficacy of galantamine-escitalopram combination in patients with Mild Cognitive Disorder and Depression. There is a possible relation between the deficit of cerebral oxygenation and depression or relation between the serotonin system and cholinergic system in relation with disease comorbidity cognitivedepression
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