Abstract
AbstractA new synthetic protocol has been developed for the synthesis of N‐formamide derivatives using ethers as a C1 synthon under metal‐free reaction conditions. The reaction is proposed to proceed through C−H functionalization, C−O cleavage, and C−N bond formation. This protocol is applicable to a variety of primary amines resulting in N‐formamides in moderate to good yields. 1,4‐dioxane was chosen as best C1 synthon after screening with various ethers. Mechanistic studies disclosed that the reaction proceeds through a radical pathway. While using α‐amino ketones a α‐alkylation product was formed rather than formylation. By replacing dioxane with Tetramethylethylenediamine (TMEDA) under standard conditions also gave the N‐formamide derivatives in moderate yields.magnified image
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