Mikronükleus Temelli Genotoksisite Testleri

Abstract

Genotoxicity assessment is an important process to keep human and animal health and aims to identify the safety of many kinds of substances. There are many in vitro mutagenicity prediction tests. The recent in vitro/in vivo genotoxicity assays and accepted common test methods may give critical information for the assessment of genotoxic and probable carcinogenic potential of suspected substances. Micronucleus (MN), MN-FISH, MN-based flow cytometry analysis done alone or done with chromosome instability assays and/or comet assay are some of assays that may be used to assess clastogenic and aneugenic effects of substances like pesticides, food additives, pharmaceuticals, chemicals used in cosmetics, veterinary drugs and living organisms like bacteria or virus. In this mini-review, the studies about the tests mentioned above are included. In summary, MNbased genotoxicity tests and accepted common test methods may provide important information for the assessment of genotoxic and probable carcinogenic potential of suspected substances.