Abstract
Antibiotic resistance reversal of multiple drug resistant bacteria using Piper longum fruit extractVinay Kumar, Varsha Shriramand Javed Mulla
Highlights
Pathogenic microbes, such as bacteria, viruses, parasites, and fungi are the causal agent of communicable diseases, which are reflected as a significant hazard to human health due to the scarcity of vaccines, inadequate chemotherapy, and an increase in resistant bacteria against antibiotics (Assob et al, 2011)
This study was aimed to screen the activity of the methanolic extract of Mikania cordata leaves (MLME) against pathogenic bacteria and Ehrlich ascites carcinoma (EAC)-induced cancer in mice
The leaves extract at 200 μg/disk concentration showed significant antibacterial effects against two Gram-positive bacteria (B. subtilis and S. lutea) and three Gramnegative bacteria (K. pneumoniae, P. vulgaris, and P. denitrificans) with the zone of inhibition ranging from 11 ± 0.816 to 13 ± 0.816 mm
Summary
Pathogenic microbes, such as bacteria, viruses, parasites, and fungi are the causal agent of communicable diseases, which are reflected as a significant hazard to human health due to the scarcity of vaccines, inadequate chemotherapy, and an increase in resistant bacteria against antibiotics (Assob et al, 2011). Utmost of the Rahman et al / Journal of Applied Pharmaceutical Science 10 (02); 2020: 112-122 cells with non-repaired damaged DNA grow, divide, and spread abnormally instead of self-destruction by programmed cell death These types of unregulated atypical cells when invading other parts of the body normally initiate the progression that is called metastasis (Hanahan et al, 2011). The management of this condition is limited to the single and/or combined use of chemotherapy, radiotherapy, and surgery. These options are advancing significantly with higher survival rates, they are more or less costly with various side effects likely the reduction of neighboring normal cells, serious post-treatment complications, and in some cases, the resurrection of chemotherapy and radiotherapy resistant secondary malignancies (Al-Mamun et al, 2016; Islam et al, 2018). The exploration of safer antitumor candidates with the least side effects and better selectivity is a big interest worldwide today
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