Abstract
Studies of experimental animals and man have provided evidence that both environmental and genetic factors are important determinants of arterial pressure. Whilst much information has been gained from detailed investigations of experimental models of hypertension, the direct applicability of such studies to the aetiology and pathogenesis of essential hypertension in man is by no means clear, and what is needed is an appropriate human model of the hypertensive process. Cross-sectional studies have demonstrated that rural/urban migration, particularly of individuals migrating from an unacculturated society to an urban environment, is frequently associated with a rise in blood pressure, and we have considered the possibility that this process might be such a model. We suggest that the factors involved in the rise in blood pressure with migration, be they genetic or environmental, are the same factors responsible for the rise in blood pressure with age seen in westernised societies, and also the factors responsible for the pathogenesis of essential hypertension (Fig. 1).
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