Abstract
Introduction: CXCR4 chemokine receptor plays a central role in mobilization and homing of stem cells. Its ligand SDF-1 (stromal derived factor-1, CXCL12) creates the gradient required for directed migration of bone marrow derived CXCR4+ fibrocytes in different organ diseases1. Recently we could show that CD34+ bone marrow derived fibrocytes play a crucial role in hepatic fibrogenesis in the BALB/c-ABCB4 -/- mouse model of sclerosing cholangitis2. With the current study we analyzed whether the migration of CD34+ fibrocytes from BALB/c-Abcb4 -/- mouse liver depends on the CXCR4-SDF-1 axis.
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