Abstract
The prognosis for corneal transplanta tion in advanced Fuchs' dystrophy and bullous keratopathy has improved dra matically in recent years. Our increased understanding of the role of the comeal endothelium and of methods to preserve it in the donor has played a vital role in this improvement. Nonetheless, there still remains the well-known clinical entity of late graft failures in conditions of primary endothelial disease. Specular microscopic studies of successful grafts in Fuchs' dys trophy tend to show a marked donor en dothelial cell loss with time, which could explain these late failures. One explana tion for this cell loss could be a spread of the donor endothelium onto the recipient side. We report the study of just such a phenomenon in rabbits.
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