Abstract
During development, neural crest cells-derived melanoblasts migrate along the dorso-lateral axis into the dermis, then cross the basal layer to reach the epidermis and differentiate into melanocytes. They finally colonize the hair follicles to become resident pigmented cells. Neoplastic transformation converts melanocytes into highly invasive melanoma cells, which can adopt two modes of interconvertible migration (mesenchymal and amoeboid). Through analysis of the coat color phenotype of natural mouse mutants and genetically modified animals, many of the genes regulating migration were identified. Deciphering of cell membrane protrusions and signaling molecules involved in melanoma cell motility was further achieved through 2D and 3D culture systems. Here, we summarize how these data allow a better understanding of the complex mechanisms controlling migration of normal and pathological cells of the melanocytic lineage.
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