Migraine-specific quality of life questionnaire and relapse of medication overuse headache.

Stefano Caproni,Ettore Beghi,Elisa Bianchi,Paola Sarchielli,Letizia M Cupini,Ilenia Corbelli,Paolo Calabresi

doi:10.1186/s12883-015-0339-8

Abstract

BackgroundThe management of Medication overuse headache (MOH) represents a difficult challenge for clinicians and headache experts, particularly for the responder rate after a successful withdrawal treatment. The purpose of this study was to investigate the role of demographic and clinical characteristics as well as the score of Migraine-Specific Quality of Life Questionnaire (MSQ), Migraine Disability Questionnaire and Leeds Dependence Questionnaire in predicting a response after a successful withdrawal treatment in patients with MOH.MethodsThis ancillary study is part of a randomized trial that demonstrated the safety and the efficacy of a 3-month treatment with sodium valproate (VPA) (800 mg/day vs placebo) in MOH. Demographic and clinical characteristics and questionnaire results were obtained from the entire sample.ResultsA significant correlation was found only between MOH relapse and the total MSQ score, the Role Preventive sub-scale and the Emotional Function sub-scale, suggesting a poorer quality of life in non responders.ConclusionA high MSQ score could be associated with a poor short-term outcome in MOH patients after a successful treatment with detoxification followed by a new treatment.

Highlights

The management of Medication overuse headache (MOH) represents a difficult challenge for clinicians and headache experts, for the responder rate after a successful withdrawal treatment
The management of MOH represents a difficult challenge for clinicians and headache experts [3]
In recent years an increasing number of studies focused on the predictors of relapse of MOH, but no reproducible results have been achieved

Summary

Introduction

The management of Medication overuse headache (MOH) represents a difficult challenge for clinicians and headache experts, for the responder rate after a successful withdrawal treatment. The purpose of this study was to investigate the role of demographic and clinical characteristics as well as the score of Migraine-Specific Quality of Life Questionnaire (MSQ), Migraine Disability Questionnaire and Leeds Dependence Questionnaire in predicting a response after a successful withdrawal treatment in patients with MOH. The management of MOH represents a difficult challenge for clinicians and headache experts [3]. Even in case of a successful withdrawal treatment, the relapse rate of MOH ranges between 24 % and 43 % (40 % during the first year after withdrawal) [4]. While in a 4-year follow-up no significant predictors were found [6], in three studies with 1-year follow-up, predictors of relapse were, respectively, a

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