Abstract
Understanding the molecular mechanisms that precede and give rise to a migraine attack is key to developing new therapeutic strategies. Advances towards this goal have recently been made through genome-wide association studies, which have identified new genetic components of migraine that highlight vascular etiologies and underline the polygenic nature of this disorder.
Highlights
Editorial summary Understanding the molecular mechanisms that precede and give rise to a migraine attack is key to developing new therapeutic strategies
The most recent Genome-wide association (GWA) study [1], which was conducted by groups including our own, has identified 38 genomic loci commonly found in humans (>5 % allele frequency) that influence migraine risk
We outline the major findings from the latest GWA study of migraine [1] and discuss what they reveal about both the pathophysiology and genetic architecture of the disease
Summary
Editorial summary Understanding the molecular mechanisms that precede and give rise to a migraine attack is key to developing new therapeutic strategies. Genome-wide association (GWA) studies are an important approach used to uncover the genetic susceptibility components of complex diseases such as migraine. The most recent GWA study [1], which was conducted by groups including our own, has identified 38 genomic loci commonly found in humans (>5 % allele frequency) that influence migraine risk.
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