Mifepristone may inhibit the midcycle gonadotropin surge at both ovarian and pituitary sites of action

Abstract

The ability of mifepristone to delay ovulation is thought to be based on the antigonadotropic effects of the drug. In the current work, late-follicular phase administration of mifepristone resulted in decrease in both circulating FSH and inhibin B, suggesting both central and ovarian sites of action.