Mifepristone combined with Gongliuxiao capsule for patients with hysteromyoma

Abstract

Objective To explore the effect of mifepristone combined with Gongliuxiao for patients with hysteromyoma.Methods 90 patients with hysteromyoma treated at our department from July,2014 to June,2015 were selected and divided into a control group (45 cases) and an observation group (45 cases) using random number table method.The control group were treated with mifepristone and the observation group with mifepristone and Gongliuxiao capsule.The short-term treatment effect was evaluated in both groups.Before and after the treatment,the maximum myoma volume,uterine volume,cell factors and sex hormone levels were compared between these two groups.Results The total effective rate was 93.33％ in the observation group and 77.78％ in the control group (P ＜ 0.05).The maximum myoma volume and uterine volume were (105.62±23.17) cm3 and (34.63±13.56) cm3 in the observation group and were (118.29±25.46) cm3 and (48.72±15.68) cm3 in the control group (P ＜ 0.05).The serum levels of TNF2 alpha and IL-22 were (21.29±10.43) ng/L and (20.36±8.56) ng/L in the observation group and were (16.69±3.17) ng/L and (33.25±13.05) ng/L in the control group,with statistical differences (P ＜ 0.05).The levels of E2 and P were (160.37±44.93) pmmol/L and (9.03±2.85) μg/L in the observation group and were (227.66±54.63) pmmol/L and (15.92±2.66) μg/L in the control group (P ＜ 0.05).There was no statistical difference in the incidence of clinical adverse reactions during the treatment period between these two groups (P ＞ 0.05).Conclusions Mifepristone combined with Gongliuxiao for patients with hysteromyoma is obviously effective and can improve the patients' endocrine function and prognosis.