Mid-to-long term safety and efficacy of Woven EndoBridge device for Treatment of intracranial wide neck aneurysms: A systematic review and meta-analysis

Abstract

BackgroundIn recent 10 years, Woven EndoBridge(WEB) device has been used as endovascular instrumentation for treating wide neck Bifurcation aneurysms. Its safety and efficacy in the mid-term (6–24 months) and long-term (more than 24 months) follow-up period have yet to be systematically reviewed. PurposeTo evaluate the WEB device safety and efficacy, relevant literature and publications were extensively reviewed, and a meta-analysis was conducted. Data resourceAll relevant literature/publications were achieved from Pubmed, Cochrane, Embase, and Web of Science databases. Results767 patients that were studied in 13 literature were included. The focus of this review was placed on the clinical and anatomic outcomes. Complete occlusion was achieved in 67.3% (95% CI, 59.0–75.5%) and 69.3% (95% CI, 55.7–82.8%) of the cases at mid- and long-term follow-up. The rate of adequate occlusion was 86.6% (95% CI, 83.0–90.2%) and 90.1% (95% CI, 85.5–94.4%) for the mid and long-term, respectively. 51 patients (8.8%; 95% CI,5.6–11.9%) and 18 (8.1%; 95% CI,0.8–15.5%) received retreatments during mid- and long-term follow-up, respectively. 410 patients from 427 (94.3%; 95% CI, 89.7–98.9%) showed favorable clinical outcomes. The all-cause mortality rate was 3.5% (95% CI, 1.4–5.6%), where only a few cases were related to the WEB implantation. The WEB device deployment was associated with an overall clinical complication rate of 4.1% (95% CI, 2.7–6.6%), 3 hemorrhagic (1.2%; 95% CI, 0.2–2.6%), and 30 thromboembolic (4.0%; 95% CI, 4.0– 6.0%) complications. ConclusionsThe findings reveal the satisfactory safety and effectiveness of the WEB device for the Treatment of wide-neck aneurysms during mid-to-long-term follow-up, indicating the high potential of the WEB device for wide application.