Mid-term and long-term therapeutic effect of endovascular therapy for acute deep vein thrombosis

Abstract

Objective: To evaluate the mid-term and long-term efficacy of endovascular treatment for acute deep vein thrombosis (DVT) of lower extremities. Methods: The clinical data of 180 patients with acute lower extremity DVT in our department from October 2007 to May 2017 were selected. The clinical outcome of interventional therapy group and control group was analyzed. 120 patients with lower extremity DVT underwent endovascular treatment (intervention group) , combined with catheter-directed thrombolysis. After stopping anticoagulation, 26 patients in interventional therapy group with thrombosis recurrence underwent endovascular treatment again, and then lifetime anticoagulant therapy. 60 patients in control group with adequate anticoagulant therapy, underwent local thrombolysis through the dorsal vein of the involved limb. All the 180 patients underwent anticoagulation treatment for 24 months. Results: The effective rate of the intervention group was significantly better than that of the control group (100% vs. 86.7%) , with significant difference (Z=113.679, P<0.05) . The patency rates of the iliac veins in intervention group after 1, 2, 5, and 10 years was significantly higher than that in control group (89.2%, 95%, 84.6%, 100% vs. 8.3%, 5%, 0%, 0%) respectively. The rate of post-thrombotic syndrome (PTS) in intervention group (13.3%) was significantly lower than that in control group (46.7%) , the difference was statistically significant. Conclusions: Endovascular treatment can effectively improve the therapeutic effect of patients with DVT and reduce the incidence of PTS in patients with acute lower extremity DVT. Therefore, endovascular treatment for deep venous thrombosis of the lower extremity is safe and effective. Key words: Deep venous thrombosis; Catheter-directed thrombolysis; Post-thrombotic syndrome; Endovascular therapy