Abstract
Intrauterine insertion of a 0.5 cm long Silastic-PVP tube containing 750 μg PGE 2 (lyophilized sodium salt) caused midterm abortion in hamsters within 48 hours. An earlier study using a similar Silastic-PVP tube delivery system showed that 200 μg of PGF 2α (Tham) was sufficient to induce abortion in 100% of pregnant hamsters (18). Prostaglandin E 2 is, therefore, about 3.5–4 times less potent than PGF 2α as an abortifacient in the hamster. The release of 3H-PGE 2 from Silastic-PVP tube in vitro and in vivo is also described. It is suggested that an increase in LH release might be one of the factors leading to luteolysis; and that either PGE 2 exerts a direct luteolytic effect or this effect is manifested after its being converted in vivo to PGF 2α.
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