Abstract

+ 4.0; p < 0.001). Paroxetine B(max) (number of serotonin transporter binding sites) was significantly correlated with HA (r =-0.326; p ~ 0.049) and approached significance for NS (r = -0.288; p = 0.084), but not with RD. Combining HA and NS scores yielded a higher correlation than using either score alone (r = -0.375; p = 0.022). Although the data are open to other interpretations, they are generally supportive of the hypothesis that a serotonergicaUy mediated dimension of personality may predispose to the development of FFSD in psychologically traumatized individuals. ously, two with benzodiazepine treatment, and one with neuroleptic treatment. Case histories and possible etiologies for panic disorder with psychosis are discussed. It is suggested that psychotic features in panic disorder could be related to dopaminergic hyperactivity. A dimensional approach is proposed where the axes of anxiety and psychosis overlap, producing a variety of clinical pictures ranging from anxiety symptoms in schizophrenia to panic attacks with psychotic features.

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