Abstract
Objective To evaluate the expression of human midkine mRNA in peripheral blood of patients with uon-small-cell lung caucer (NSCLC).Methods The levels of midkine mRNA expression in 78 patients with NSCLC,35 patients with lung benign lesion and 30 healthy volunteers were evaluated by SYBR Green Ⅰ real-time reverse transcription polymerase chain reaction (PCR).Results The relative midkine mRNA expression in patients with NSCLC (6.749 ± 1.117) was significantly lower than in patients with benign pulmonary disease ( 7.988 ± 0.633 ) and healthy wolunteers ( 8.156 ± 0.525 ) ( both P ＜0.05 ),but there was no significant differenee between the latter two groups ( P ＞ 0.05 ).Moreover,higher relative midkine mRNA expression in NSCLC patients was correlated with elinic al stages,differentiation,and metastasis ( P ＜ 0.05 ),but not with sex,age,smoking habit and pathological types ( P ＞0.05).Conclusion These findings support our hypothesis that midkine mRNA is a promising biomarker in peripheral blood of patients with NSCLC. Key words: Midkine; Tumor marker; Non-small-cell lung cancer
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