Abstract
Background: Midkine (MK), a heparin-binding growth factor, has various functions such as migration of inflammatory cell and anti-apoptotic effect. We reported serum MK levels were increased in patients with heart failure and were independently associated with adverse cardiac events. The aim of this study was to examine the role of MK in cardiac hypertrophy and remodeling. Methods and Results: We generated transgenic mice overexpressing MK (MK-Tg) in a heart-specific manner. Transverse aortic constriction (TAC) or sham operation were performed in MK-Tg and wild-type (WT) mice.
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