Abstract
Background/aim: We aimed to determine Helicobacter pylori prevalence in gastric malignant disease and to examine its value in the etiology. Infection with Helicobacter pylori is associated with an increased risk of gastric adenocarcinoma and gastric lymphoma. Materials and methods: We retrospectively examined the surgical specimens of 42 patients with malignant gastric tumors, who had been hospitalized in the second and fifth Department of General Surgery, Ministry of Health Ankara Training and Research Hospital, between 1998 and 2005 and treated with gastrectomy. Histological assessment and Helicobacter pylori density determinations were made according to Lauren and Sydney classifications, respectively. Results: Thirty-two had gastric carcinoma and 10 had gastric non-Hodgkin lymphoma. Helicobacter pylori infection was present in 10 (33.3%) of the gastric carcinoma patients and 7 (70%) of the gastric lymphoma patients. The density of Helicobacter pylori was ‘1' in nine gastric carcinoma and six gastric lymphoma cases, and ‘2' in one gastric carcinoma and one gastric lymphoma case. Helicobacter pylori prevalence is significantly higher in lymphoma cases than carcinoma cases. Diffuse type gastric carcinoma is more correlated with Helicobacter pylori than the intestinal type, and Helicobacter pylori density increases in conjunction with an increase in the gastric carcinoma clinical stage, but these findings were not significant. Conclusion: A high prevalence of Helicobacter pylori among the gastric lymphoma patients confirms the role of Helicobacter pylori in gastric lymphoma genesis.
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