Midazolam-induced decrease in hypermetabolic state stewards anticonvulsive therapy for interictal patterns in severe acute brain injury: A pilot MR perfusion study

Abstract

Background: PET and SPECT scans have been used in small cohorts as complementary metabolic marker of status epilepticus among patients with ictal-interictal EEG patterns along the continuum (IIC). Some periodic/rhythmic discharges deserve to be abated using anticonvulsants, while some other IIC patterns only reflect underlying fixed brain lesions without superimposed ongoing cerebral insult. Perfusion mapping is an imperfect surrogate for metabolism, but is more readily available.