Abstract
Mid-infrared hyperspectral imaging has in the past decade emerged as a promising tool for medical diagnostics. In this work, nonlinear frequency upconversion based hyperspectral imaging in the 6 to 8 µm spectral range is presented for the first time, using both broadband globar and narrowband quantum cascade laser illumination. AgGaS2 is used as the nonlinear medium for sum frequency generation using a 1064 nm mixing laser. Angular scanning of the nonlinear crystal provides broad spectral coverage at every spatial position in the image. This study demonstrates the retrieval of series of monochromatic images acquired by a silicon based CCD camera, using both broadband and narrowband illumination and a comparison is made between the two illumination sources for hyperspectral imaging.
Highlights
Hyperspectral imaging in the mid-infrared (MIR) range is a promising tool for a wide range of applications in medical diagnostics [1], such as histopathological study of tissue samples employed for cancer diagnostics [2,3,4,5]
This study demonstrates the retrieval of series of monochromatic images acquired by a silicon based CCD camera, using both broadband and narrowband illumination and a comparison is made between the two illumination sources for hyperspectral imaging
This paper is, to the best of our knowledge, the first demonstration of mid-infrared hyperspectral imaging based on upconversion technology in 6 to 8 μm spectral range
Summary
Hyperspectral imaging in the mid-infrared (MIR) range is a promising tool for a wide range of applications in medical diagnostics [1], such as histopathological study of tissue samples employed for cancer diagnostics [2,3,4,5]. Scanning of the phase match condition is implemented by rotation of the nonlinear crystal relative to its ĉ-axis, which enables imaging of every pixel within the field of view with full spectral information encoded. This approach is only viable for imaging when performing the frequency conversion in the Fourier plane of the system (a translation in the Fourier plane coursed by crystal rotation only results in an angle in the image plane, i.e. the camera position). The spectral and spatial resolution is evaluated for the two cases and a comparison between their performances is made
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