Abstract
AbstractBy attempts to construct new antimicrobial agents, a series of mono‐and dibromo of 3′‐(oxiranyl, hydrazide, oxadiazolo and pyrazolo)‐methylene‐spiro[isobenzofuran‐1,2′‐quinazoline]‐3,4′(3′H)‐dione derivatives were synthesized through the interaction between 6‐bromo and/or 6,8‐dibromo‐spiroiso‐benzofuran‐1,2′‐quinazolindione with carbon electrophiles, namely, ethyl chloroacetate, epichlorohydrin, chloroacetyl chloride and phosphorus pentasulfide (P2S5). Reaction of ethylester of spiroquinazolindione with hydrazine hydrate under MW‐US and UV reaction condition (green tool saves time and energy) to afford spiroquinazolindione hydrazide that used as preparatory materials for the synthesis of novel spiroquinazolin‐dione. Most of the created compounds were evaluated in vitro for their antibacterial and antifungal activity. The 6‐bromo or 6,8‐dibromo quinazolin‐3,4‐dione nucleus bears oxirane hydrazino acetyl, hydrazide, oxadiazole and pyrazole moieties at position (3) and were the most potent against the gram‐positive bacteria, gram‐negative bacteria, and fungi comparable to Chloramphenicol and Fluconazole.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.