Abstract
One-pot, three-component preparation of the pyrrolizidine and pyrrolizinone derivatives in moderate to good yield is reported. The synthesis is facilitated by microwave irradiation of proline, aromatic aldehyde, and 1,3-diketone such as 2-arylmethylene-indene-1,3-dione and 4-hydroxycoumarin in 1,4-dioxane or xylene. This method provides a quick access to the multi-functionalized pyrrolizidines and pyrrolizinones.
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