Microwave-Induced Synthesis of Various Quinoline Derivatives: Green Methodologies in Organic Synthesis

Abstract

In the present chapter, we have focused on microwave-assisted synthesis of quinoline-based heterocyclic compounds because this technique has gained popularity over nonconventional techniques for the rapid synthesis of products. With the help of this technique, many researchers have accelerated organic synthesis, and since the past couple of years a large number of research papers have appeared in scientific journals. This has proved the utility of microwave-assisted synthesis in various branches of chemistry. Microwave-assisted organic synthesis may be helpful to increase the yield, decrease reaction time and minimize the formation of hazardous by-products. With the help of this technique, solvent-free reactions can be easily carried out for eliminating toxicity and flammability issues, which are the major concerns with the use of classical solvents. Quinoline compounds serve both as biomimetics and as reactive pharmacophores of numerous drugs and are associated with several biological activities. Considering these facts and the several applications of microwave-induced synthesis in organic and pharmaceutical chemistry, in the present chapter, we have exclusively focused on the synthesis of various quinoline-based heterocyclic compounds.