Microwave-induced 1,3-dipolar intramolecular cycloadditions of N-substituted oximes, nitrones, and azomethine ylides for the chiral synthesis of functionalized nitrogen heterocycles

Abstract

Highly stereoselective intramolecular cycloadditions of unsaturated N-substituted oximes, nitrones, and azomethine ylides on the surface of silica gel without a solvent, which have been conducted under microwave irradiation, to produce functionalized tricyclic isoxazolidines fused with a pyrroline or piperidine ring in good yields, are presented.