Abstract
Novel phthalonitrile and zinc (II) phthalocyanines containing pharmacological active molecules like morpholine and triazole were prepared and characterized. The new compounds were obtained by both microwave assisted and conventional method. The structure of compounds were characterized by elemental analysis, IR, UV/vis, 1H NMR, 13C NMR and Mass spectroscopy techniques. All compounds were screened for anti-xanthine oxidase (anti-XO) activities. The compound 3 showed promising XO inhibition with IC50 value as 0.082 ± 0.004 mM. Phthalocyanine compounds did not show XO inhibition due to high aggregation tendency and low solubility.
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