Microwave-assisted synthesis and evaluation of indole based benzofuran scaffolds as antimicrobial and antioxidant agents

Abstract

A novel series of indole based benzofuran derivatives has been synthesized under microwave irradiation and conventional conditions. The structures of the compounds were established on the basis of 1HNMR, 13C NMR, IR and mass spectral data. The analogues were evaluated for their in vitro antimicrobial activity against two gram-positive bacteria, two gram-negative bacteria and two fungal strains. The same series was screened for in vitro antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH). Most of the title compounds exhibited promising antimicrobial and antioxidant activities.