Microwave-Assisted One-Pot Synthesis of Octahydroquinazolinone Derivatives Using Molybdenum Oxide Nanoparticles in Solvent-Free Condition

Abstract

Molybdenum oxide nanoparticle has been shown to be an inexpensive, efficient and mild catalyst for the one-pot synthesis of octahydroquinazolinone derivatives using dimedone, urea/thiourea and appropriate aromatic aldehydes under microwave-irradiation. Molybdenum oxide nanoparticles were prepared by electrochemical reduction method in which parameters such as current density, solvent polarity, distance between electrodes, and concentration of stabilizers are used to control the size of nanoparticles. Molybdenum oxide nanoparticle has been shown to be an inexpensive, efficient and mild catalyst for the one-pot synthesis of octahydroquinazolinone derivatives using dimedone, urea/thiourea and appropriate aromatic aldehydes under microwave-irradiation.