Microwave‐assisted one‐pot multicomponent synthesis of 2‐(‐4‐oxo‐2‐(1‐(2‐oxo‐2h‐chromen‐3‐yl) ethylidene)hydrazono)thiazolidin‐5‐yl) acetic acid derivatives and their antiviral activity

Abstract

AbstractA novel series of hydrazonothiazolidinyl acetic acid derivatives were synthesized via a straightforward microwave irradiated one‐pot multicomponent reaction approach using substituted 3‐acetylcoumarins (1a‐l), thiosemicarbazide (2), and maleic anhydride (3). The synthesis was carried out by using sodium acetate and acetic acid as a solvent at 70°C, afforded target molecules in a shorter reaction time, simple reaction workup with high yields. All the synthesized compounds were well characterized by analytical data (1H, 13C NMR and mass spectra). In vitro antiviral activity of thiazolidinyl acetic acid derivatives were evaluated against a broad panel of human viruses in different cell lines among which compound 4d exhibited excellent activity against Herpes simplex virus‐1.