Microwave‐assisted facile synthesis of propargylamine library by robust nitro functionalized cross‐linked polystyrene resin supported Cu NPs

Abstract

AbstractIn the present investigation, we study catalytic activity of copper nanoparticles stabilized onto a nitro functionalized polystyrene resin (Cu NPs@ Nitro‐Resin). The size of stabilized copper nanoparticles was found between 3 and 9 nm. This work reports a cost‐effective and sustainable protocol for the synthesis of propargylamines. Herein, we have developed microwave‐assisted synthesis of propargylamine from 3 components coupling of aldehyde, alkynes, and amines (A3 coupling) in truly heterogeneous catalytic system. Reaction parameters, such as solvent, catalyst concentration reaction time, and recyclability, were investigated, and reaction conditions were optimized. The present method has advantages such as environmentally benign, ease to handle, short reaction time (≈25 min), excellent yields (98%), low E‐factor (0.15), and high atom economy (94%).